A multi-step continuous flow synthesis of pomalidomide

Continuous flow multi-step organic synthesis

The multi-step synthesis of complex organic compounds from simpler precursors is one of the outstanding accomplishments and ongoing challenges of synthetic organic chemistry. Through the development and invention of synthesis strategies, methods and technologies, increasingly complex molecules can be assembled with designed structures and functions for a variety of medicinal, agrochemical and m...

Semi-continuous multi-step synthesis of lamivudine.

We report the first continuous flow synthesis of lamivudine, an antiretroviral drug used in the treatment of HIV/AIDS and hepatitis B. The key intermediate (5-acetoxy oxathiolane) was prepared by an integrated two step continuous flow process from l-menthyl glyoxalate hydrate in a single solvent, in 95% overall conversion. For the crucial glycosidation reaction, using pyridinium triflate as the...

single-step synthesis of multi-component spirobarbiturates using ionic liquids and synthesis of substituted pyridine filled with catalysts supported on solid substrate

in this thesis, a better reaction conditions for the synthesis of spirobarbiturates catalyzed by task-specific ionic liquid (2-hydroxy-n-(2-hydroxyethyl)-n,n-dimethylethanaminium formate), calcium hypochlorite ca(ocl)2 or n-bromosuccinimide (nbs) in the presence of water at room temperature by ultrasonic technique is provided. the design and synthesis of spirocycles is a challenging task becaus...

Multi-step flow fusion

The aim of this work is to estimate dense displacement fields over long video shots. Put in sequence they are useful for representing point trajectories but also for propagating (pulling) information from a reference frame to the rest of the video. Highly elaborated optical flow estimation algorithms are at hand, and they were applied before for dense point tracking by simple accumulation, howe...

Two-step continuous-flow synthesis of CuInSe2 nanoparticles in a solar microreactor